What is prayer? A lot of people will say that prayer is just talking to God like you would talk to a friend. In many ways, this is true. In many ways it isn’t. If you’ve ever meditated, or practiced mindfulness, that is the beginning of prayer. Meditation is about emptying your mind, and prayer is about filling it back up again with God’s thoughts. Prayer requires mindfulness and reason to work together to seek the mind of God (1 Corinthians 2:16).